Highly stereoselective, cobalt(III)-directed Mannich additions in water yielding α-methylamino acid products
| Autor: | Stephanie Oerum, Søren Furbo, Jesper Bendix, Peter Krabbe, Magnus Schau-Magnussen, Anders Hammershøi |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Double bond
Imine Molecular Conformation chemistry.chemical_element Crystallography X-Ray Medicinal chemistry Diethyl malonate Acetoacetates Nitroparaffins Inorganic Chemistry Mannich Bases chemistry.chemical_compound Coordination Complexes Organic chemistry chemistry.chemical_classification Addition reaction Aqueous solution Nitromethane Water Stereoisomerism Cobalt Malonates chemistry Stereoselectivity Methane |
| Zdroj: | Dalton transactions (Cambridge, England : 2003). 42(1) |
| ISSN: | 1477-9234 |
| Popis: | Highly stereoselective and rapid (1 min) addition reactions to the imine double bond of 2-(methylimino)acetate complexes [L(4)Co(O(2)CCH=NCH(3))](2+) [L(4) = (en)(2) (7), (tren) (11)] were achieved in aqueous solution with nitromethane, ethyl 3-oxobutanoate or diethyl malonate. The molecular structures of two product complexes, rac-(Δ*-R(C)*-S(N)*)-[Co(en)(2)(O(2)CCH[CH(2)NO(2)]NHCH(3))]ZnCl(4) and rac-(Δ*-R(C)*-S(N)*)-[Co(en)(2)(O(2)CCH[CH(2)COCH(3)]NHCH(3))]ZnCl(4), were established by X-ray diffraction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|