Degradation of the Twin-Arginine Translocation Substrate YwbN by Extracytoplasmic Proteases of Bacillus subtilis
| Autor: | Jan Maarten van Dijl, Laxmi Krishnappa, Carmine G. Monteferrante |
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| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG, Microbes in Health and Disease (MHD), Translational Immunology Groningen (TRIGR) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Proteases
Protein Folding GRAM-POSITIVE BACTERIA Proteolysis medicine.medical_treatment PROTEIN EXPORT PATHWAY Protein Export Pathway Bacillus subtilis Biology Applied Microbiology and Biotechnology Twin-arginine translocation pathway Bacterial Proteins QUALITY-CONTROL medicine Extracellular TAT PATHWAY Protease Ecology medicine.diagnostic_test Membrane Transport Proteins biology.organism_classification Protein Transport Biochemistry Peroxidases Cytoplasm ESCHERICHIA-COLI SECRETION MEMBRANE SYSTEM Food Science Peptide Hydrolases Biotechnology |
| Zdroj: | Applied and environmental microbiology, 78(21), 7801-7804. AMER SOC MICROBIOLOGY |
| ISSN: | 0099-2240 |
| Popis: | Bacterial twin-arginine translocases can export fully folded proteins from the cytoplasm. Such proteins are usually resistant to proteolysis. Here we show that multiple extracellular proteases degrade the B. subtilis Tat substrate YwbN. This suggests either that secreted YwbN is not fully folded or that folded YwbN exposes protease cleavage sites. |
| Databáze: | OpenAIRE |
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