Protective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury
| Autor: | Edgar S.L. Liu, Hwai-Ping Sheng, Chi Hin Cho, H.L. So, Yini Ye, Shiuh-Sheng Lee, C.C.M. Cho, Y. Li |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Angelica sinensis Administration Oral Nitric Oxide Synthase Type II CCL4 Pharmacology digestive system Plant Roots General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley chemistry.chemical_compound Mice Malondialdehyde medicine Animals General Pharmacology Toxicology and Pharmaceutics Carbon Tetrachloride Acetaminophen Glycosaminoglycans Mice Inbred ICR biology Dose-Response Relationship Drug Plant Extracts Alanine Transaminase General Medicine Glutathione biology.organism_classification digestive system diseases Rats Nitric oxide synthase chemistry Biochemistry Alanine transaminase Liver Carbon tetrachloride biology.protein Chemical and Drug Induced Liver Injury Nitric Oxide Synthase medicine.drug Drugs Chinese Herbal |
| Zdroj: | Life sciences. 69(6) |
| ISSN: | 0024-3205 |
| Popis: | A polysaccharides-enriched fraction from the root of Angelica sinensis, which is known for its antiulcer action on the gastrointestinal tract, was isolated and studied for its hepato-protective effect in rodents. Intra-gastric administration of Angelica sinensis polysaccharides-enriched fraction (AP) at the doses of 50 or 75 mg/kg dose-dependently prevented liver toxicity induced by acetaminophen in mice but did not affect the serum acetaminophen concentration. It normalized the rises of serum alanine transferase (ALT) and hepatic nitric oxide synthase (NOS) activities and the decrease of glutathione level in the liver. It also reduced the hepatic malondialdehyde (MDA) concentration. The protective effect was less evident in the carbon tetrachloride (CCl4)-treated animals including mice and rats. In the rat the elevated serum ALT level was unaffected though the MDA level was similarly reduced by the higher dose of AP. In these animals, CCl4 increased the hepatic glutathione level instead while the NOS activity remained unchanged. These findings suggest that the pathogenic mechanisms of both acetaminophen and CCl4 are different. AP is more effective in the protection against liver damage induced by acetaminophen, which is associated with the glutathione depletion and nitric oxide synthase activation in the liver. |
| Databáze: | OpenAIRE |
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