The Moroccan Genetic Disease Database (MGDD): a database for DNA variations related to inherited disorders and disease susceptibility
| Autor: | Khalid Gabi, Hicham Charoute, Hassan Rouba, Malika Fakiri, Omar Abidi, Abdelhamid Barakat, Halima Nahili |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Relational database Population Ethnic group Disease Biology computer.software_genre Article symbols.namesake Molecular genetics Databases Genetic Genetic variation Genetics medicine Humans Genetic Predisposition to Disease education Genetics (clinical) Genetic association education.field_of_study Polymorphism Genetic Database Genetic Diseases Inborn Morocco Mendelian inheritance symbols computer |
| Zdroj: | European Journal of Human Genetics. 22:322-326 |
| ISSN: | 1476-5438 1018-4813 |
| DOI: | 10.1038/ejhg.2013.151 |
| Popis: | National and ethnic mutation databases provide comprehensive information about genetic variations reported in a population or an ethnic group. In this paper, we present the Moroccan Genetic Disease Database (MGDD), a catalogue of genetic data related to diseases identified in the Moroccan population. We used the PubMed, Web of Science and Google Scholar databases to identify available articles published until April 2013. The Database is designed and implemented on a three-tier model using Mysql relational database and the PHP programming language. To date, the database contains 425 mutations and 208 polymorphisms found in 301 genes and 259 diseases. Most Mendelian diseases in the Moroccan population follow autosomal recessive mode of inheritance (74.17%) and affect endocrine, nutritional and metabolic physiology. The MGDD database provides reference information for researchers, clinicians and health professionals through a user-friendly Web interface. Its content should be useful to improve researches in human molecular genetics, disease diagnoses and design of association studies. MGDD can be publicly accessed at http://mgdd.pasteur.ma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|