Adult-diagnosed Chronic Granulomatous Disease: The Need to Increase Awareness
| Autor: | Charles N. Webb, Joseph Baxter, Derek M. Smith |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
021110 strategic
defence & security studies business.industry medicine.drug_class Antibiotics 0211 other engineering and technologies Public Health Environmental and Occupational Health Genetic disorder 02 engineering and technology General Medicine Disease medicine.disease Immune thrombocytopenia Respiratory burst 03 medical and health sciences 0302 clinical medicine Chronic granulomatous disease Concomitant Immunology Medicine 030212 general & internal medicine business |
| Zdroj: | Military Medicine. 188:e410-e411 |
| ISSN: | 1930-613X 0026-4075 |
| DOI: | 10.1093/milmed/usab073 |
| Popis: | Chronic granulomatous disease is genetic disorder characterized by the inability of phagocytes to produce sufficient oxidative burst needed to kill intracellular organisms. Patients have recurrent, life-threatening infections involving multiple systems including the lungs, skin, lymph nodes, and liver. The majority of patients with chronic granulomatous disease are diagnosed in childhood although some may present in adulthood due to a milder phenotype. Unfortunately, these patients may also present with concomitant autoimmune diseases. We describe a 48-year-old woman with a history of immune thrombocytopenia and systemic lupus erythematosus on immunosuppressive therapy. She developed subsequent bacterial and fungal infections initially attributed to immunosuppressive drugs. Further evaluation revealed the diagnosis of chronic granulomatous disease. We review the diagnosis and treatment of chronic granulomatous disease in hopes to increase awareness of this disease in adulthood in order to initiate potential life-saving prophylactic antibiotics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|