The reliability of glomerular filtration rate measured from plasma clearance: a multi-centre study of 1,878 healthy potential renal transplant donors
| Autor: | Richard S. Lawson, Hayley Snelling, Nagabhushan Seshadri, Claire A. Hooker, Nigel Williams, Mark D. J. Neilly, Mark C. Barnfield, Ravin Sobnack, Bethany Howard, Gregory Shabo, Laura Perry, Andrew Irwin, A. Michael Peters, Neva H. Patel, Surendra Dave, Thomas Grüning |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Metabolic Clearance Rate Coefficient of variation Urology Renal function urologic and male genital diseases Body Mass Index Young Adult Sex Factors Living Donors Humans Medicine Radiology Nuclear Medicine and imaging Multi centre Aged Retrospective Studies Body surface area Plasma clearance urogenital system business.industry Body Weight Healthy subjects Reproducibility of Results Extracellular Fluid General Medicine Middle Aged Kidney Transplantation Filtration fraction Benchmarking Health Renal transplant Female business Glomerular Filtration Rate |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging. 39:715-722 |
| ISSN: | 1619-7089 1619-7070 |
| Popis: | The objective of the study was to undertake a clinical audit of departmental performance in the measurement of glomerular filtration rate (GFR) using the coefficient of variation (CV) of extracellular fluid volume (ECFV) as the benchmark. ECFV is held within narrow limits in healthy subjects, narrower than GFR, and should therefore have a low CV. Fifteen departments participated in this retrospective study of healthy renal transplant donors. Data were analysed separately for men (n ranged from 28 to 115 per centre; total = 819) and women (n = 28–146; 1,059). All centres used the slope-intercept method with blood sample numbers ranging from two to five. Subjects did not fast prior to GFR measurement. GFR was scaled to body surface area (BSA) and corrected for the single compartment assumption. GFR scaled to ECFV was calculated as the terminal slope rate constant and corrected for the single compartment assumption. ECFV/BSA was calculated as the ratio of GFR/BSA to GFR/ECFV. The departmental CVs of ECFV/BSA and GFR/BSA ranged from 8.3 to 25.8% and 12.8 to 21.9%, respectively, in men, and from 9.6 to 21.1% and 14.8 to 23.7%, respectively, in women. Both CVs correlated strongly between men and women from the same centre, suggesting department-specific systematic errors. GFR/BSA was higher in men in 14 of 15 centres, whereas GFR/ECFV was higher in women in 14 of 15 centres. Both correlated strongly between men and women, suggesting regional variation in GFR. The CV of ECFV/BSA in normal subjects is a useful indicator of the technical robustness with which GFR is measured and, in this study, indicated a wide variation in departmental performance. |
| Databáze: | OpenAIRE |
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