The association between sarcopenia susceptibility and polymorphisms of FTO , ACVR2B , and IRS1 in Tibetans
| Autor: | Youfeng Wen, Xianpeng Zhang, Ying Chen, Wenhui Li, Liping Ye, Xin Li, Yaqiong Jiang |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Activin Receptors Type II Genetic traits Alpha-Ketoglutarate-Dependent Dioxygenase FTO fat mass and obesity‐associated protein (FTO) insulin receptor substrate 1 (IRS1) QH426-470 Tibet Polymorphism Single Nucleotide Fat mass activin type IIB receptor (ACVR2B) sarcopenia single‐nucleotide polymorphism (SNP) Internal medicine Genetics Humans Medicine Molecular Biology Genetics (clinical) Aged business.industry nutritional and metabolic diseases Skeletal muscle Original Articles Middle Aged Hypoxia (medical) musculoskeletal system medicine.disease Obesity IRS1 body regions Endocrinology medicine.anatomical_structure Sarcopenia Insulin Receptor Substrate Proteins Female Original Article medicine.symptom business human activities ACVR2B Tibetan |
| Zdroj: | Molecular Genetics & Genomic Medicine, Vol 9, Iss 8, Pp n/a-n/a (2021) Molecular Genetics & Genomic Medicine |
| ISSN: | 2324-9269 |
| DOI: | 10.1002/mgg3.1747 |
| Popis: | Background Hypoxia within the plateau has a negative effect on skeletal muscle and may play a role in the development of sarcopenia in humans. Tibetans having lived in the Qinghai‐Tibet Plateau for thousands of years, are a high‐risk group for sarcopenia; however, they have a distinctive suite of genetic traits that enable them to tolerate environmental hypoxia and are genetically significantly different from Han Chinese and other lowland populations. Sarcopenia has been consistently found to be associated with single‐nucleotide polymorphisms, but few studies have investigated the role of single‐nucleotide polymorphisms in a range of muscle phenotypes and sarcopenia in Tibetan peoples. Methods Our study aimed to investigate the skeletal muscle mass and fat mass of 160 Tibetans (80 men and 80 women) from Lhasa (altitude of 3600 meters) and analyze the association between the polymorphisms of fat mass and obesity protein (FTO) rs9939609, FTO rs9936385, activin type IIB receptor (ACVR2B) rs2276541, insulin receptor substrate 1 (IRS1) 2943656 and sarcopenia. Result FTO rs9939609 and rs9936385 polymorphisms were associated with lower limb skeletal muscle mass and sarcopenia for Tibetan women, and TT homozygotes had a higher risk for sarcopenia. But ACVR2B rs2276541 and IRS1 2943656 polymorphisms were unassociated with sarcopenia in Tibetan. Conclusion In Tibetans, FTO rs9939609 and rs9936385 polymorphisms were associated with sarcopenia, and ACVR2B rs2276541 and IRS1 2943656 polymorphisms were unassociated with sarcopenia. Our study aimed to investigate the skeletal muscle mass and fat mass of 160 Tibetans (80 men and 80 women) from Lhasa (altitude of 3600 meters) and analyze the association between polymorphisms of FTO rs9939609, FTO rs9936385 ACVR2B rs2276541, IRS1 2943656 and sarcopenia. We found that FTO rs9939609 and rs9936385 polymorphisms were associated with lower limb skeletal muscle mass and sarcopenia for Tibetan women, and TT homozygotes had a higher risk for sarcopenia. But ACVR2B rs2276541 and IRS1 2943656 polymorphisms were unassociated with sarcopenia in Tibetan. |
| Databáze: | OpenAIRE |
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