Comparison of Microbiota Variation in Korean Healthy Adolescents with Adults Suggests Notable Maturity Differences
Autor: | Jin Sook Lee, Seungyoon Nam, Joo-Won Jeong, Joo-Wook Kim, Dae Ho Lee, Jung Ho Kim |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Korean adolescents Human Microbiome Project Adolescent co-occurrence network Firmicutes 030106 microbiology Population Zoology Context (language use) Disease Gut flora Biochemistry developmental biology 03 medical and health sciences RNA Ribosomal 16S Genetics Humans Microbiome population microbiome science education Molecular Biology Research Articles education.field_of_study biology Sequence Analysis RNA Microbiota Bacteroidetes biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology Molecular Medicine Biotechnology |
Zdroj: | OMICS : a Journal of Integrative Biology |
ISSN: | 1557-8100 |
Popis: | Comparative studies of microbiome variation in world populations and different developmental stages of organisms are essential to decipher the linkages among microbiome, health, and disease. Notably, the gut microbiota are believed to mature in early life. In this context, we compared the gut microbiota diversity in Korean adolescent healthy samples (KAHSs) to healthy Korean adults (HKAs) as well as the Human Microbiome Project healthy samples (HMPHSs), the latter being one of the largest adult cohorts, based on organismal composition, alpha- and beta-diversities, function/pathway prediction analysis, and co-occurrence networks. We found that the gut microbiota compositions, including the ratios of firmicutes to bacteroidetes, between KAHSs and HMPHSs were different, and the diversities of KAHSs were less than those of HMPHSs. The predicted functions, for example, secondary bile acid synthesis and insulin signaling of KAHSs and HMPHSs, were also significantly different. Genus-level networks showed that co-occurrences among different taxa more frequently happened in HMPHSs than in KAHSs. Even though both KAHSs and HMPHSs represent healthy microbiomes, comparisons showed substantial differences, likely implicating different diets, environments, and demographics. Interestingly, we observed lower microbial diversities and less frequent co-occurrences among different taxa in KAHSs than adult HMPHSs and HKAs. These new findings collectively suggest that the adolescent gut microbiota in the present Korean sample did not reach the extent of maturity of adult microbiota diversity. In all, further population studies of microbiome variation across geographies and developmental stages are warranted, and should usefully inform future diagnostics and therapeutics innovation targeting the microbiome. |
Databáze: | OpenAIRE |
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