Comparative manufacture and cell-based delivery of antiretroviral nanoformulations
| Autor: | Georgette D. Kanmogne, Tatiana K. Bronich, Alexander V. Kabanov, Xin Ming Liu, Ram S. Veerubhotla, Andrea Martinez-Skinner, Shantanu Balkundi, Han Chen, R. Lee Mosley, Upal Roy, JoEllyn M McMillan, Ari S. Nowacek, Howard E. Gendelman |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
manufacturing techniques
Cyclopropanes Medicine (General) Pyridines Chemistry Pharmaceutical Pharmaceutical Science Indinavir 02 engineering and technology Pharmacology chemistry.chemical_compound International Journal of Nanomedicine Drug Discovery Nanotechnology nanoformulated antiretroviral therapy media_common Original Research 0303 health sciences Nanoart Histocytochemistry virus diseases General Medicine 021001 nanoscience & nanotechnology 3. Good health Nanomedicine Alkynes nanotoxicology 0210 nano-technology Oligopeptides medicine.drug Drug Materials science Efavirenz Anti-HIV Agents Cell Survival media_common.quotation_subject Atazanavir Sulfate Biophysics Bioengineering Biomaterials 03 medical and health sciences Sonication R5-920 medicine Humans 030304 developmental biology Ritonavir monocyte-derived macrophage Macrophages Organic Chemistry Significant difference Atazanavir Benzoxazines chemistry Nanoparticles human immunodeficiency virus type one Cell based |
| Zdroj: | International Journal of Nanomedicine Scopus-Elsevier International Journal of Nanomedicine, Vol 2011, Iss default, Pp 3393-3404 (2011) |
| ISSN: | 1178-2013 1176-9114 |
| Popis: | Shantanu Balkundi1, Ari S Nowacek1, Ram S Veerubhotla1, Han Chen2, Andrea Martinez-Skinner1, Upal Roy1, R Lee Mosley1,3, Georgette Kanmogne1, Xinming Liu1,3,4, Alexander V Kabanov3,4, Tatiana Bronich3,4, JoEllyn McMillan1, Howard E Gendelman1,31Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA; 2Center for Biotechnology, University of Nebraska-Lincoln, Lincoln, NE, USA; 3Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, NE, USA; 4Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USAAbstract: Nanoformulations of crystalline indinavir, ritonavir, atazanavir, and efavirenz were manufactured by wet milling, homogenization or sonication with a variety of excipients. The chemical, biological, immune, virological, and toxicological properties of these formulations were compared using an established monocyte-derived macrophage scoring indicator system. Measurements of drug uptake, retention, release, and antiretroviral activity demonstrated differences amongst preparation methods. Interestingly, for drug cell targeting and antiretroviral responses the most significant difference among the particles was the drug itself. We posit that the choice of drug and formulation composition may ultimately affect clinical utility.Keywords: human immunodeficiency virus type one, nanotoxicology, monocyte-derived macrophage, nanoformulated antiretroviral therapy, manufacturing techniques |
| Databáze: | OpenAIRE |
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