Managing High-Altitude Pulmonary Edema with Oxygen Alone: Results of a Randomized Controlled Trial
| Autor: | Velu Nair, Surinderpal Singh, Ruchira Mukherjee, Konchok Norgais, Amul Gupta, Vikrant Singh, Srinivasa Bhattachar, Sagarika Patyal, Uday Yanamandra, Sushma Yanamandra, Deepak Mulajkar, Bhushan Chopra, R.S. Grewal |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Nifedipine Physiology medicine.medical_treatment Hypertension Pulmonary Vasodilator Agents Anti-Inflammatory Agents 030204 cardiovascular system & hematology Altitude Sickness Bed rest Dexamethasone law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Pharmacotherapy Randomized controlled trial law High-altitude pulmonary edema medicine Combined Modality Therapy Humans Altitude sickness business.industry Altitude Public Health Environmental and Occupational Health Oxygen Inhalation Therapy 030208 emergency & critical care medicine General Medicine medicine.disease Pulmonary edema Pulmonary hypertension Surgery Oxygen Treatment Outcome Anesthesia business |
| Zdroj: | High altitude medicinebiology. 17(4) |
| ISSN: | 1557-8682 |
| Popis: | Yanamandra, Uday, Velu Nair, Surinderpal Singh, Amul Gupta, Deepak Mulajkar, Sushma Yanamandra, Konchok Norgais, Ruchira Mukherjee, Vikrant Singh, Srinivasa A. Bhattachar, Sagarika Patyal, and Rajan Grewal. High-altitude pulmonary edema management: Is anything other than oxygen required? Results of a randomized controlled trial. High Alt Med Biol. 17:294-299, 2016.-Treatment strategies for management of high-altitude pulmonary edema (HAPE) are mainly based on the observational studies with only two randomized controlled trials, thus the practice is very heterogeneous and individualized as per the choice of treating physician. To compare the response to different modalities of therapy in patients with HAPE in a randomized controlled manner. We conducted an open-label, randomized noninferiority trial to compare three modalities of therapy (Therapy 1: supplemental O2 with oral dexamethasone 8 mg q8 hours [n = 42], Therapy 2: supplemental O2 with sustained release oral nifedipine 20 mg q8 hours [n = 41], and Therapy 3: only supplemental O2 [n = 50]). Bed rest was mandated in all patients. The study was conducted in a cohort of previously healthy young lowlander males at an altitude of 3500 m. Baseline characteristics of the patients were comparable in the study arms. Complete response was defined as clinical and radiological resolution of features of HAPE, no oxygen dependency, a normal 6-minute walk test (6MWT) on 2 consecutive days, and normal two-dimensional echocardiography. Results were compared by analysis of variance using SPSS version 16.0. There was no statistical difference in duration of therapy to complete response between the three groups (Therapy 1: 8.1 ± 4.0 days, Therapy 2: 6.7 ± 3.9 days, Therapy 3: 6.8 ± 3.2 days; p = 0.15). There were no deaths in any of the groups. We conclude that oxygen and bed rest alone are adequate therapy for HAPE and that adjuvant pharmacotherapy with either dexamethasone or nifedipine does not hasten recovery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|