Association of an emergency department febrile neutropenia intervention protocol with time to initial antibiotic treatment
| Autor: | Justin A. Seltzer, Demetrios N. Kyriacou, Olga Frankfurt |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty business.industry medicine.drug_class Antibiotics General Medicine Emergency department medicine.disease Triage Confidence interval Anti-Bacterial Agents Cohort Studies Intervention (counseling) Internal medicine Neoplasms Emergency Medicine medicine Absolute neutrophil count Humans business Emergency Service Hospital Febrile neutropenia Cohort study Febrile Neutropenia Retrospective Studies |
| Zdroj: | Academic emergency medicine : official journal of the Society for Academic Emergency MedicineREFERENCES. 29(1) |
| ISSN: | 1553-2712 |
| Popis: | BACKGROUND Earlier initial antibiotic treatment for febrile neutropenia is associated with improved clinical outcomes. This study was conducted to evaluate the association of an emergency department (ED) intervention protocol with time to initial antibiotic treatment for febrile neutropenia patients. METHODS We conducted a cohort study of adult ED febrile neutropenia patients before and after implementation of an intervention protocol. Analyses included comparison of means and medians, Kaplan-Meier estimates, multivariable regression analyses, interrupted time-series analyses, and causal mediation analyses. The intervention protocol included specific triage and process-of-care actions to reduce the primary outcome of time to initial antibiotic treatment. RESULTS There were 69 patients in the 12-month preintervention period and 52 patients in the 8-month postintervention period. The mean (±SD) times to initial antibiotics were 197.6 (±85.4) min for the preintervention group and 97.7 (±51.0) min for the postintervention group (difference of 99.9 min with 95% confidence interval [CI] = 73.5 to 126.4, p |
| Databáze: | OpenAIRE |
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