Functional Characterization of Human Tc0, Tc1 and Tc2 CD8+T Cell Clones: Control of X4 and R5 HIV Strain Replication
| Autor: | Michèle Février, Antoine Talarmin, Yves Rivière, Sylvie Le Borgne, Christian Marty |
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| Rok vydání: | 2004 |
| Předmět: |
Male
T cell Immunology Biology Virus Replication Virus Interleukin 21 Th2 Cells T-Lymphocyte Subsets medicine Humans Immunology and Allergy Cytotoxic T cell RNA-Directed DNA Polymerase T lymphocyte Th1 Cells Phenotype Virology Clone Cells medicine.anatomical_structure Viral replication HIV-1 Cytokines Female CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | Journal of Clinical Immunology. 24:272-280 |
| ISSN: | 0271-9142 |
| Popis: | CD8(+) T lymphocytes have the potential ability to inhibit human immunodeficiency virus (HIV) replication, by secreting soluble(s) factor(s) known as CD8(+) T lymphocyte antiviral factor (CAF). A panel of CD8(+) and CD4(+) T cell clones from HIV1-infected and uninfected donors were generated to better define the phenotype of CAF-producing cells. We first verified that the different CD4(+) T cell subsets (Th0, Th1, and Th2) were productively infected by X4 and R5 virus strains. X4 viral replication in CD4(+) T cells was controlled by the three CD8(+) T cell subsets (Tc0, Tc1, and Tc2); however, the frequency of Tc clones controlling R5 strain was much lower with a dramatic absence of this activity among Tc clones from uninfected donor. Finally, capacity to control viral replication showed an heterogeneity: some clones could control both virus strains, some controlled only the X4 virus, whereas the majority exerted no suppressive activity. |
| Databáze: | OpenAIRE |
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