Varicella-Zoster Viral Meningitis Mimicking Lymphoma
| Autor: | Eric Oksenhendler, Lionel Galicier, V Leymarie, François Sigaux, M E Noguera, Félix Agbalika, Sophie Park |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Epstein-Barr Virus Infections Herpesvirus 3 Human Herpesvirus 4 Human Cancer Research Pathology medicine.medical_specialty viruses Biology medicine.disease_cause Herpes Zoster Polymerase Chain Reaction Virus Central Nervous System Neoplasms Diagnosis Differential hemic and lymphatic diseases medicine Viral meningitis Humans Ganciclovir Lymphoma AIDS-Related T-cell receptor Varicella zoster virus virus diseases Hematology Gene rearrangement medicine.disease Meningitis Viral Virology Lymphoma Basophilic Oncology DNA Viral Meningitis |
| Zdroj: | Leukemia & Lymphoma. 44:1793-1795 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.1080/10428190310001606521 |
| Popis: | We report the case of a 30-year-old HIV-infected man admitted for a meningeal syndrome and a zoster rash. The CSF had cytological features suggesting a primary CNS lymphoma (PCNSL). The large lymphoid cells had a fine chromatin with nucleoli, a basophilic cytoplasm with azurophilic granules and high mitotic activity. Several arguments demonstrated the viral origin of the meningitis: the large lymphoid cells were of T origin with no evidence of clonal TCR gamma gene rearrangement. The PCR was positive for Varicella-Zoster Virus (VZV) and EBV DNA. Clinical evolution was favorable under acyclovir. We should be cautious in the differential diagnosis between viral meningitis and PCNSL. |
| Databáze: | OpenAIRE |
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