Endothelial-cell inflammation and damage by reactive oxygen species are prevented by propofol via ABCA1-mediated cholesterol efflux
| Autor: | Chih-Hung Lin, Chan-Yen Kuo, Chih-Peng Hsu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.medical_treatment Inflammation high-density lipoprotein Pharmacology 03 medical and health sciences chemistry.chemical_compound High-density lipoprotein medicine Animals Hypnotics and Sedatives Propofol Aorta reactive oxygen species chemistry.chemical_classification Reactive oxygen species biology Cholesterol Endothelial Cells General Medicine rat aortic endothelial cells Rats Endothelial stem cell 030104 developmental biology chemistry ABCA1 biology.protein ATP-Binding Cassette Transporters lipids (amino acids peptides and proteins) medicine.symptom cholesterol efflux Research Paper ATP Binding Cassette Transporter 1 Lipoprotein |
| Zdroj: | International Journal of Medical Sciences |
| ISSN: | 1449-1907 |
| DOI: | 10.7150/ijms.24659 |
| Popis: | Background: Cholesterol efflux efficiency, reactive oxygen species, and inflammation are closely related to cardiovascular diseases. Our aim was to investigate the effect of propofol on cholesterol-loaded rat aortic endothelial cells after high-density lipoprotein treatment in vitro. Methods and Results: The results showed that propofol promoted cholesterol efflux and ameliorated inflammation and reactive oxygen species overproduction according to the analysis of p65 nuclear translocation and a 2′,7′-dichlorofluorescin diacetate assay, respectively. Conclusions: These results provide a possible explanation for the anti-inflammatory, antioxidant, and cholesterol efflux-promoting effects of propofol on rat aortic endothelial cells after incubation with high-density lipoprotein. |
| Databáze: | OpenAIRE |
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