Combination of Ledipasvir and Sofosbuvir for Treatment of Hepatitis C Virus Genotype 1 Infection: Systematic Review and Meta-Analysis
| Autor: | Joshua A. Dubland, Ramesh Saeedi, Masoud Yousefi, Supna Sandhu, Siegfried R. Erb, Daniel T. Holmes, David L. Kendler, Wing C. Peter Kwan, Jo-Ann Ford, Ali Mojebi-Mogharar, Morris Pudek, Eric M. Yoshida |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Fibroblast growth factor 23 Time Factors Sustained Virologic Response Specialties of internal medicine Hepacivirus Gastroenterology Bone remodeling 0302 clinical medicine Odds Ratio 030212 general & internal medicine Aged 80 and over Bone mineral Lamivudine General Medicine Entecavir Middle Aged Hepatitis C Treatment Outcome RC581-951 Drug Therapy Combination Female 030211 gastroenterology & hepatology Ledipasvir Hypophosphatemia medicine.drug Adult medicine.medical_specialty Adolescent Genotype Urinary system Antiviral Agents Young Adult 03 medical and health sciences Internal medicine Ribavirin Vitamin D and neurology medicine Humans Aged Fluorenes Chi-Square Distribution Hepatology business.industry medicine.disease Meta-analysis Benzimidazoles Therapy Sofosbuvir business |
| Zdroj: | Annals of Hepatology, Vol 16, Iss 2, Pp 188-197 (2017) |
| ISSN: | 1665-2681 |
| Popis: | Background and aim. The combination of Sofosbuvir (SOF) and Ledipasvir (LDV) has been lead to considerable enhancement of treatment of hepatitis C virus (HCV) genotype 1 infection. A meta-analysis of the currently available studies was undertaken with the aim to evaluate the antiviral efficacy of SOF/LDV therapy for 12 or 24 weeks with or without Ribavirin (RBV) in patients with HCV genotype 1 infection.Material and methods. In this meta-analysis, we searched databases including PubMed, Scopus, Science Direct and Web of Science using appropriate keywords. All papers which evaluated the efficacy of combination therapy of SOF/LDV with or without RBV for 12 or 24 weeks among patients with HCV genotype 1 infection were included.Results. The 20 published articles were assessed for eligibility and finally 10 articles pooling 2248 participants were included in this meta-analysis. Pooled SVR12 for four SOF/LDV regimens were 95% (95%CI = 93%-97%) for 12 weeks of treatment with SOF/LDV, 97% (95%CI = 95%-98%) for 24 weeks of treatment with SOF/LDV, 96% (95%CI = 94%-97%) for 12 weeks of treatment with SOF/ LDV/RBV and 98% (95%CI = 97%-99%) for 24 weeks of treatment with SOF/LDV/RBV. Only in treatment regimen of SOF/LDV for 12 weeks, cirrhosis had a significant effect on the SVR12 (OR = 0.21, 95%CI = 0.07-0.66). Furthermore, NS5A resistance-associated substitutions at baseline were associated with decrease in the rate of SVR (OR = 0.31, 95%CI = 0.2-0.5).Conclusions. The Interferon-free regimen of SOF/LDV for 12 or 24 weeks with or without RBV is highly effective for treatment of patients with HCV genotype 1 infection. |
| Databáze: | OpenAIRE |
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