Synthesis and antimicrobial evaluation of some new substituted purine derivatives
| Autor: | Arzu Karayel, Süheyla Özbey, Zeynep Ates-Alagoz, Meral Tuncbilek, Nurten Altanlar |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Staphylococcus aureus
Oxiconazole Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests Bacillus subtilis medicine.disease_cause Biochemistry Microbiology Structure-Activity Relationship Anti-Infective Agents Drug Discovery medicine Candida albicans Molecular Biology Escherichia coli biology Chemistry Organic Chemistry Antimicrobial biology.organism_classification Corpus albicans Purines Molecular Medicine Methicillin Resistance Antibacterial activity medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry. 17:1693-1700 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/j.bmc.2008.12.050 |
| Popis: | A series of 8,9-disubstituted adenines (4, 5, 8), 6-substituted aminopurines (10-13) and 9-(p-fluorobenzyl/cyclopentyl)-6-substituted aminopurines (16, 17, 19-30) have been prepared and the antimicrobial activities of these compounds against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA, standard and clinical isolate), Bacillus subtilis, Escherichia coli and Candida albicans were evaluated. 6-[(N-phenylaminoethyl)amino]-9H-purine (12) which has no substitution at N-9 position and 9-cyclopentyl-6-[(4-fluorobenzyl)amino]-9H-purine (24) exhibited excellent activity against C. albicans with MIC 3.12 microg/mL. These compounds displayed better antifungal activity than that of standard oxiconazole. Furthermore, compound 22 carrying 4-chlorobenzylamino group at the 6-position of the purine moiety exhibited comparable antibacterial activity with that of the standard ciprofloxacin against both of the drug-resistant bacteria (MRSA, standard and clinical isolate). |
| Databáze: | OpenAIRE |
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