A Multicenter Survey of Type I Diabetes Mellitus in Chinese Children
| Autor: | Xiangrong Liang, Tang Li, Geli Liu, Wenhui Song, Xiaoli Yan, Mireguli Maimaiti, Ying Xin, Guimei Li, Feihong Luo, Lanwei Cui, Li Liu, Baosheng Yu, Huamei Ma, Junfen Fu, Hui Yao, Zhiya Dong, Shaoke Chen, Qin Zhang, Ling Hou, Zhixin Zhang, Pik To Cheung, Xiaobo Chen, Xinran Cheng, Liyang Liang, Xiaoping Luo, Yu Yang, Xiangyun Peng, Xiuzhen Li, Chunxiu Gong, Ruimin Chen, Hongwei Du, Huifeng Zhang, Hanyang Wei, Pin Li, Feng Xiong |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Insulin pump
Blood Glucose Male Pediatrics medicine.medical_specialty China insulin Diabetic ketoacidosis Adolescent endocrine system diseases type 1 diabetes Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin Infusion Systems diabetic ketoacidosis children medicine Humans Hypoglycemic Agents survey 030212 general & internal medicine Child Original Research Type 1 diabetes education business.industry Insulin Type i diabetes mellitus Autoantibody nutritional and metabolic diseases medicine.disease RC648-665 Diabetes Mellitus Type 1 Treatment Outcome Child Preschool Cohort Multicenter survey Female business |
| Zdroj: | Frontiers in Endocrinology, Vol 12 (2021) Frontiers in Endocrinology |
| ISSN: | 1664-2392 |
| Popis: | PurposeTo investigate the features and treatment status of children with type 1 diabetes mellitus (T1DM) in China.MethodsWe recruited patients ResultsA total of 1,603 children (755 males and 848 females) with T1DM participated in this survey. Of these, 834 (52.03%) of the patients exhibited diabetic ketoacidosis (DKA) at onset, while 769 patients (47.97%) did not exhibit DKA (non-DKA) at onset. There was a higher proportion of females (55.71%) in the cohort of patients exhibiting DKA at onset than in the non-DKA cohort (49.33%). The mean age of patients exhibiting DKA at presentation was 7.12 ± 0.14 years; this was significantly younger than that in non-DKA group (7.79 ± 0.15 years; P < 0.005). The frequency of DKA in 3 years old, 3-7 years old, and 7 years old or more was 77.21%, 26.17%, and 37.62%, respectively. Upon initial diagnosis, 29.4%, 15.2% and 11.8% of patients showed positivity for glutamic acid decarboxylase antibody (GADA), Insulin autoantibodies (IAA), or islet cell antibody (ICA), respectively. During six months follow-up, 244 patients (15.21%) reported receiving insulin pump therapy, and more than 60% of patients monitored their blood glucose levels less than 35 times per week. Although the majority of patients had no problems with obtaining insulin, 4.74% of the children surveyed were not able to receive insulin due to financial reasons, a shortage of insulin preparations, or the failure of the parents or guardians to acquire the appropriate medicine.ConclusionDKA is more common in very young children. Treatment and follow-up of T1DM in China still face very serious challenges. |
| Databáze: | OpenAIRE |
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