Receptor-Effector Coupling Dysfunctions in Alzheimer's Disease
| Autor: | Cora O'Neill, Richard F. Cowburn, Christopher J. Fowler, Anita Garlind |
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| Rok vydání: | 1996 |
| Předmět: |
Cerebellum
Effector General Neuroscience Brain Inositol 1 4 5-Trisphosphate Disease Biology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound medicine.anatomical_structure History and Philosophy of Science chemistry Alzheimer Disease Second messenger system medicine Humans Signal transduction Receptor Neurotransmitter Neuroscience Protein kinase C Signal Transduction |
| Zdroj: | Annals of the New York Academy of Sciences. 786:294-304 |
| ISSN: | 1749-6632 0077-8923 |
| Popis: | There is now good evidence that in the AD brain, a number of neurotransmitter effector systems are defective. Such abnormalities include defective G, protein and protein kinase C function as well as a drastically reduced level of receptors for the second messenger Ins(1,4,5) P3. Such changes are probably not restricted to the late stages of the disease, and are found in regions of the brain that show little histopathological abnormality, such as the cerebellum. Whether these changes precede or are secondary to primary histopathological changes such as beta-amyloid deposition is not as yet clear. What is clear, however, is that such signal transduction abnormalities are likely to negate therapeutic benefits in clinical strategies based upon the tenet of neurotransmitter replacement. |
| Databáze: | OpenAIRE |
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