Increased mitochondrial oxidative damage in patients with sporadic amyotrophic lateral sclerosis
| Autor: | Takahiko Murata, Chigumi Ohtsuka, Yasuo Terayama |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Central Nervous System Male Pathology medicine.medical_specialty Mitochondrial Diseases Ubiquinone Mitochondrion medicine.disease_cause Pathogenesis Central nervous system disease chemistry.chemical_compound Cerebrospinal fluid Degenerative disease parasitic diseases medicine Humans Amyotrophic lateral sclerosis Coenzyme Q10 business.industry Amyotrophic Lateral Sclerosis Middle Aged medicine.disease Mitochondria Oxidative Stress Neurology chemistry Female Neurology (clinical) Energy Metabolism business Oxidation-Reduction Biomarkers Oxidative stress |
| Zdroj: | Journal of the Neurological Sciences. 267:66-69 |
| ISSN: | 0022-510X |
| Popis: | To investigate whether mitochondrial oxidative damage contributes to the pathogenesis of sporadic amyotrophic lateral sclerosis (sALS), we used high-performance liquid chromatography with an electrochemical detector to measure the concentrations of the reduced and oxidized forms of coenzyme Q10 (CoQ10) in the cerebrospinal fluid (CSF) of 30 patients with sALS and 17 age-matched controls with no neurological diseases. The percentage of oxidized CoQ10 in the CSF of sALS patients were significantly greater than those in the CSF of controls (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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