Priming of Azabicycle Biosynthesis in the Azinomycin Class of Antitumor Agents

Autor:	Dioscar Delgado, Vasudha Sharma, Vishruth Gowda, Shogo Mori, Keshav K. Nepal, Coran M. H. Watanabe, Dinesh Simkhada, Gilbert T. Kelly
Rok vydání:	2017
Předmět:	0301 basic medicine Pyrrolidines Stereochemistry Amino-Acid N-Acetyltransferase Priming (immunology) Glutamic Acid Naphthalenes 01 natural sciences Biochemistry Pyrrolidine Substrate Specificity 03 medical and health sciences chemistry.chemical_compound Gene Knockout Techniques Biosynthesis Bacterial Proteins Acetyl Coenzyme A Antineoplastic Agents Alkylating Antibiotics Antineoplastic Molecular Structure 010405 organic chemistry Chemistry Acetylation Dipeptides Phosphotransferases (Carboxyl Group Acceptor) Aldehyde Oxidoreductases Recombinant Proteins Streptomyces 0104 chemical sciences 030104 developmental biology Drug Design Mutation Biocatalysis Intercellular Signaling Peptides and Proteins Peptides Azabicyclo Compounds
Zdroj:	Biochemistry. 56(6)
ISSN:	1520-4995
Popis:	The biosynthesis of the azabicyclic ring system of the azinomycin family of antitumor agents represents the “crown jewel” of the pathway and is a complex process involving at least 14 enzymatic steps. This study reports on the first biosynthetic step, the inroads, in the construction of the novel aziridino [1,2-a]pyrrolidine, azabicyclic core, allowing us to support a new mechanism for azabicycle formation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b50dc558ac6eaa5729864e70629cad https://pubmed.ncbi.nlm.nih.gov/28135072 Zobrazit plný text záznamu