Cytokines (IL-6, IL-8, TNF): early and reliable predictors of severe acute pancreatitis
| Autor: | Pankaj K. Singh, Anant Indaram, Nakechand Pooran, Simmy Bank |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Pancreatic disease Time Factors medicine.medical_treatment Gastroenterology Severity of Illness Index Diagnosis Differential Predictive Value of Tests Internal medicine medicine Humans Interleukin 8 Prospective Studies Interleukin 6 biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha Interleukin-8 Interleukin Reproducibility of Results Middle Aged medicine.disease Endocrinology Cytokine Pancreatitis Case-Control Studies Acute Disease biology.protein Acute pancreatitis Tumor necrosis factor alpha Female business |
| Zdroj: | Journal of clinical gastroenterology. 37(3) |
| ISSN: | 0192-0790 |
| Popis: | Severe acute pancreatitis is associated with a high mortality, especially when compared with mild acute pancreatitis. Early intervention in patients with severe acute pancreatitis has been shown to improve mortality. The value of cytokines (interleukin [IL]-6, IL-8 and tumor necrosis factor [TNF]-alpha) in diagnosing severe acute pancreatitis at an early stage was studied.Thirty-six patients with acute pancreatitis were prospectively evaluated. Age-matched controls were obtained from healthy volunteers. Levels of IL-6, IL-8, and TNF-alpha were obtained within 24 hours of admission. Ranson's prognostic signs and Bank's clinical criteria were used to differentiate patients into mild and severe pancreatitis.There was significant difference in IL-6 levels between controls and mild pancreatitis, controls and severe pancreatitis, and mild and severe pancreatitis. IL-8 levels were significantly different between controls and severe pancreatitis and mild and severe pancreatitis. There was no significant difference between controls and mild pancreatitis. The results for TNF-alpha were similar to the findings for IL-8.IL-6, IL-8, and TNF can be used independently in differentiating mild acute pancreatitis from early severe acute pancreatitis. |
| Databáze: | OpenAIRE |
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