| Autor: |
Alexander L. Greninger, Richard K. Plemper, Katherine S. Lee, Ting Y. Wong, Michael T. Winters, Brynnan P. Russ, Fredrick Heath Damron, James Denvir, Justin R. Bevere, Luis Martinez-Sobrido, Jordi B. Torrelles, Ivan Martinez, Holly A. Cyphert, Julien Sourimant, Alexander M. Horspool, Chengjin Ye, Theodore Kieffer |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
bioRxiv |
| DOI: |
10.1101/2021.05.05.442784 |
| Popis: |
SUMMARYSARS-CoV-2 variants of concern (VoCs) are impacting responses to the COVID-19 pandemic. Here we present a comparison of the SARS-CoV-2 USA-WA1/2020 (WA-1) strain with B.1.1.7 and B.1.351 VoCs and identify significant differences in viral propagationin vitroand pathogenicityin vivousing K18-hACE2 transgenic mice. Passive immunization with plasma from an early pandemic SARS-CoV-2 patient resulted in significant differences in the outcome of VoC-infected mice. WA-1-infected mice were protected by plasma, B.1.1.7-infected mice were partially protected, and B.1.351-infected mice were not protected. Serological correlates of disease were different between VoC-infected mice, with B.1.351 triggering significantly altered cytokine profiles than other strains. In this study, we defined infectivity and immune responses triggered by VoCs and observed that early 2020 SARS-CoV-2 human immune plasma was insufficient to protect against challenge with B.1.1.7 and B.1.351 in the mouse model. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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