Differences in Liver Impairment Between Adults and Children with Dengue Infection
| Autor: | Rosario Martínez Vega, Benjaluck Phonrat, Jittima Dhitavat, Weerapong Phumratanaprapin, Vorada Choovichian, Maleerat Sutherat |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Bilirubin 030231 tropical medicine Aspartate transaminase Gastroenterology Dengue fever Dengue Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Virology Internal medicine medicine Humans 030212 general & internal medicine Child Retrospective Studies Hepatitis Liver injury biology business.industry Liver Diseases Incidence (epidemiology) Articles medicine.disease Surgery Infectious Diseases chemistry Alanine transaminase biology.protein Female Parasitology Liver function business |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 94:1073-1079 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.15-0507 |
| Popis: | Dengue infection (DI) is a major vector-borne disease in southeast Asia and an important cause of morbidity. The complications such as hepatic impairment are common, and because the physiology of the liver differs between children and adults, the DI-associated liver impairments might be expected to differ as well. This study aims to compare the differences in liver impairment between adults and children with DI. We retrospectively studied 158 adults and 79 children with serologically confirmed DI admitted to the Bangkok Hospital for Tropical Diseases from 2008 to 2012. In total, 93% of adults and 87% of children exhibited abnormal liver enzyme levels during hospitalization. Overall, 76 (42.4%) adults and 16 (20.3%) children had dengue hemorrhagic fever (DHF). Compared with children, adults with dengue fever (DF) presented a significantly higher incidence of liver function impairment (alanine transaminase [ALT] > 2 × upper limit of normal [ULN]) (47.1% versus 25.5%), hepatitis (ALT > 4 × ULN) (29.4% versus 12.8%), and severe hepatitis (aspartate transaminase [AST]/ALT > 10 × ULN) (16.5% versus 4.3%). Children with DHF showed a significantly higher incidence of liver function impairment due to AST derangement than did adults (100% versus 73%). There were no differences in the total bilirubin, albumin, or total protein levels between adults and children. Liver enzymes normalized significantly more slowly in adults, and AST recovery was faster than ALT. In conclusion, liver function impairment was more common among adults than children with DF. As the severity progressed to DHF, liver injury became more common in children. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|