Histamine secretion from mast cells stimulated with somatostatin

Autor: T. A. Kassessinoff, Frederick L. Pearce
Rok vydání: 1988
Předmět:
Zdroj: Agents and Actions. 23:211-213
ISSN: 1420-908X
0065-4299
DOI: 10.1007/bf02142543
Popis: Histamine release from isolated mast cells stimulated with somatostatin resembled that induced by other basic agents. The process was rapid, independent of added calcium or phospholipids, non-cytotoxic, species and tissue specific, not mediated through cell-fixed antibodies or glucoreceptors, and inhibited by antagonists of the polyamine receptor. Somatostatin and other polycations may then act through a common receptor or binding site on the mast cell membrane.
Databáze: OpenAIRE