The influence of thyroid function on the coagulation system and its clinical consequences
| Autor: | Ellen A. Fliers, Laura P. B. Elbers, Suzanne C. Cannegieter |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Thyroid Hormones endocrine system endocrine system diseases medicine.medical_treatment Thyroid Gland 030209 endocrinology & metabolism 030204 cardiovascular system & hematology blood coagulation 03 medical and health sciences 0302 clinical medicine Von Willebrand factor Risk Factors Internal medicine Fibrinolysis Atrial Fibrillation Medicine Animals Humans hyperthyroidism Risk factor biology business.industry Thyroid Hematology Venous Thromboembolism Blood Coagulation Disorders medicine.disease Prognosis Venous thrombosis medicine.anatomical_structure Embolism Cardiovascular Diseases Cardiology biology.protein fibrinolysis hypothyroidism venous thrombosis Thyroid function hemorrhage business Hormone |
| Zdroj: | Journal of Thrombosis and Haemostasis, 16(4), 634-645 |
| DOI: | 10.1111/jth.13970 |
| Popis: | Summary: Several studies indicate that low plasma levels of thyroid hormone shift the hemostatic system towards a hypocoagulable and hyperfibrinolytic state, whereas high levels of thyroid hormone lead to more coagulation and less fibrinolysis. Low levels of thyroid hormone thereby seem to lead to an increased bleeding risk, whereas high levels, by contrast, increase the risk of venous thromboembolism. Hypothyroidism leads to a higher incidence of acquired von Willebrand's syndrome and with increasing levels of free thyroxine, levels of fibrinogen, factor VIII and von Willebrand factor, amongst others, increase gradually, to the extent that they may lead to symptomatic venous thromboembolism in patients with hyperthyroidism. Here, we discuss the literature on the effect of thyroid hormone on the hemostatic system and the associated risk of bleeding and venous thromboembolism. Patients with hypothyroidism are at increased risk of developing bleeding complications, which could be relevant in patients undergoing invasive procedures. Furthermore, physicians should be aware of the possibility of hyperthyroidism as an underlying risk factor for venous thromboembolism, especially in unexplained cases. Clinical studies are needed to further investigate the significance for general practice of these findings. Besides the effects of hyperthyroidism on venous thromboembolism, its effects on embolism secondary to atrial fibrillation are described. |
| Databáze: | OpenAIRE |
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