The ‘magic tail’ of G protein-coupled receptors: an anchorage for functional protein networks
| Autor: | Laurent Fagni, Aline Dumuis, Joël Bockaert, Philippe Marin |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
GTPase-activating protein
G protein Allosteric regulation Biophysics Receptors Cell Surface Ena/VASP homology domain-containing protein Computational biology Biology Scaffolding Proteomics Models Biological Biochemistry Rhodopsin-like receptors PSD95-disc large-zona occludens domain-containing protein Transduction (genetics) Allosteric Regulation GTP-Binding Proteins Structural Biology Genetics Animals Humans G protein-coupled receptor Receptor Molecular Biology Targeting Receptor Cross-Talk Cell Biology Signaling Protein Structure Tertiary hormones hormone substitutes and hormone antagonists Signal Transduction |
| Zdroj: | FEBS Letters. 546:65-72 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/s0014-5793(03)00453-8 |
| Popis: | All cell types express a great variety of G protein-coupled receptors (GPCRs) that are coupled to only a limited set of G proteins. This disposition favors cross-talk between transduction pathways. However, GPCRs are organized into functional units. They promote specificity and thus avoid unsuitable cross-talk. New methodologies (mostly yeast two-hybrid screens and proteomics) have been used to discover more than 50 GPCR-associated proteins that are involved in building these units. In addition, these protein networks participate in the trafficking, targeting, signaling, fine-tuning and allosteric regulation of GPCRs. To date, proteins that interact with the GPCR C-terminus are the most abundant and are the focus of this review. |
| Databáze: | OpenAIRE |
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