Kallikrein-binding protein suppresses growth of hepatocellular carcinoma by anti-angiogenic activity
| Autor: | Baohe Zhu, Xia Yang, Lei Lu, Chaoyang Li, Guoquan Gao, Shuhuan Fang, Jian Xing Ma, Weibin Cai, Zhonghan Yang |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Cancer Research Carcinoma Hepatocellular Angiogenesis Angiogenesis Inhibitors Apoptosis Endogeny Neovascularization Mice Cell Line Tumor medicine Animals Humans Serpins Neovascularization Pathologic Chemistry Binding protein Liver Neoplasms Kallikrein biochemical phenomena metabolism and nutrition Hypoxia-Inducible Factor 1 alpha Subunit medicine.disease Molecular biology digestive system diseases Gene Expression Regulation Neoplastic Oncology Cell culture Hepatocellular carcinoma medicine.symptom Neoplasm Transplantation |
| Zdroj: | Cancer Letters. 257:97-106 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2007.07.008 |
| Popis: | Effect of kallikrein-binding protein (KBP), an endogenous angiogenic inhibitor, on the growth of hepatocellular carcinoma and the possible mechanism were investigated. KBP inhibited proliferation and induced apoptosis of endothelial cells, but had no effect on the proliferation and apoptosis of hepatocarcinoma cell line HepG2. Intraperitoneal injection of KBP significantly suppressed the tumor growth and inhibited intratumoral neovascularization both in grafted hepatocarcinoma mice and xenografted hepatocarcinoma athymic mice. Moreover, KBP reduced expression of VEGF and HIF-1alpha nuclear translocation in HepG2 cells and xenografts. Down-regulation of VEGF in tumor cells through inhibiting HIF-1alpha may represent a novel mechanism for the anti-angiogenic and anti-tumor activity of KBP. |
| Databáze: | OpenAIRE |
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