Flavonoids as an effective sensitizer for anti-cancer therapy: insights into multi-faceted mechanisms and applicability towards individualized patient profiles

Autor: Kevin Zhai, Martin Péč, Lenka Koklesova, Alena Liskova, Basma Abdellatif, Miroslava Šudomová, Olga Golubnitschaja, Manaal Siddiqui, Erik Kudela, Aranka Brockmueller, Marek Samec, Kamil Biringer, Laura Kate Gadanec, Dietrich Büsselberg, Sherif T. S. Hassan, Frank A. Giordano, Peter Kubatka, Anthony Zulli, Mehdi Shakibaei
Rok vydání: 2021
Předmět:
0301 basic medicine
medicine.medical_specialty
Flavonols
medicine.medical_treatment
Phytochemicals
Cancer therapy
Anti-cancer agents
Context (language use)
Review
Flavanols
Targeted therapy
Therapy efficacy
03 medical and health sciences
Signalling pathways
0302 clinical medicine
Chalcones
Anti-inflammation
Drug Discovery
Health care
Disease management
Anthocyanidins
Medicine
Chemotherapy
Disease management (health)
Intensive care medicine
Health economy
Health policy
Flavonoids
Predictive preventive personalized medicine (3PM/PPPM)
Radiotherapy
business.industry
Biochemistry (medical)
Drug-sensitizing effect
Therapy resistance
COVID-19
Flavones
Isoflavonoids
Anti-viral
Nano-carrier delivery
030104 developmental biology
030220 oncology & carcinogenesis
Cancer management
Flavanones
Immunotherapy
business
Anti-bacterial
Tertiary Prevention
Zdroj: The EPMA Journal
ISSN: 1878-5077
Popis: Cost-efficacy of currently applied treatments is an issue in overall cancer management challenging healthcare and causing tremendous economic burden to societies around the world. Consequently, complex treatment models presenting concepts of predictive diagnostics followed by targeted prevention and treatments tailored to the personal patient profiles earn global appreciation as benefiting the patient, healthcare economy, and the society at large. In this context, application of flavonoids as a spectrum of compounds and their nano-technologically created derivatives is extensively under consideration, due to their multi-faceted anti-cancer effects applicable to the overall cost-effective cancer management, primary, secondary, and even tertiary prevention. This article analyzes most recently updated data focused on the potent capacity of flavonoids to promote anti-cancer therapeutic effects and interprets all the collected research achievements in the frame-work of predictive, preventive, and personalized (3P) medicine. Main pillars considered are:- Predictable anti-neoplastic, immune-modulating, drug-sensitizing effects;- Targeted molecular pathways to improve therapeutic outcomes by increasing sensitivity of cancer cells and reversing their resistance towards currently applied therapeutic modalities.
Databáze: OpenAIRE
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