Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons
| Autor: | Juan Antonio Sánchez-Alcañiz, Cristina García-Frigola, Oscar Marín, Manuel Valiente, Giorgia Bartolini, Catarina Osório |
|---|---|
| Přispěvatelé: | European Research Council, Ministerio de Ciencia y Tecnología (España), Ministerio de Economía y Competitividad (España), Wellcome Trust |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Receptor ErbB-4 Interneuron Lamination Pyramidal cell Biology Inhibitory postsynaptic potential General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences GABA Mice 0302 clinical medicine Cell Movement Interneurons cortical plate medicine Biological neural network Animals GABAergic Neurons lcsh:QH301-705.5 Migration Inhibition Neuregulins Cerebral Cortex pyramidal cell Pyramidal Cells Intracellular Signaling Peptides and Proteins Receptor Protein-Tyrosine Kinases Anatomy Cerebral cortex Mice Inbred C57BL Erbb4 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) nervous system Recurrent thalamo-cortical resonance Neuregulin GABAergic Cortical plate Neuroscience 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Bartolini, G, Sánchez-Alcañiz, J A, Osório, C, Valiente, M, García-Frigola, C & Marín, O 2017, ' Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons ', Cell Reports, vol. 18, no. 5, pp. 1157-1170 . https://doi.org/10.1016/j.celrep.2016.12.089 Repisalud Instituto de Salud Carlos III (ISCIII) Cell reports, vol. 18, no. 5, pp. 1157-1170 Cell Reports Cell Reports, Vol 18, Iss 5, Pp 1157-1170 (2017) |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2016.12.089 |
| Popis: | Summary Neural circuits in the cerebral cortex consist of excitatory pyramidal cells and inhibitory interneurons. These two main classes of cortical neurons follow largely different genetic programs, yet they assemble into highly specialized circuits during development following a very precise choreography. Previous studies have shown that signals produced by pyramidal cells influence the migration of cortical interneurons, but the molecular nature of these factors has remained elusive. Here, we identified Neuregulin 3 (Nrg3) as a chemoattractive factor expressed by developing pyramidal cells that guides the allocation of cortical interneurons in the developing cortical plate. Gain- and loss-of-function approaches reveal that Nrg3 modulates the migration of interneurons into the cortical plate in a process that is dependent on the tyrosine kinase receptor ErbB4. Perturbation of Nrg3 signaling in conditional mutants leads to abnormal lamination of cortical interneurons. Nrg3 is therefore a critical mediator in the assembly of cortical inhibitory circuits. Graphical Abstract Highlights • Nrg3 acts a short-range chemoattractive molecule for cortical interneurons • Nrg3 functions through ErbB4 to attract interneurons into the cortical plate • Interneurons prefer Cxcl12 over Nrg3 during tangential migration • Disruption of Nrg3 signaling causes abnormal interneuron lamination in the cortex The integration of interneurons in the developing cerebral cortex depends on signals generated by pyramidal cells. In this study, Bartolini et al. identify Neuregulin 3 as a developmentally regulated factor that controls the migration of interneurons into the cortical plate and influences their final laminar distribution. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|