Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization

Autor: Dongchang Zhang, Jian Xing Ma, Craig E. Crosson, Stephen Gee, Yan Li, G Gao
Rok vydání: 2001
Předmět:
Vascular Endothelial Growth Factor A
Time Factors
genetic structures
Angiogenesis
medicine.medical_treatment
Endothelial Growth Factors
Biochemistry
Neovascularization
chemistry.chemical_compound
Ischemia
Diabetic retinopathy
Structural Biology
Rats
Inbred BN
Pigment epithelium-derived factor
Lymphokines
Neovascularization
Pathologic
Vascular Endothelial Growth Factors
Growth factor
Vascular endothelial growth factor
Vascular endothelial growth factor A
medicine.symptom
Blotting
Western
Biophysics
Hyperoxia
Angiogenic inhibitor
Retina
PEDF
Retinal Diseases
Genetics
medicine
Animals
Nerve Growth Factors
Eye Proteins
Molecular Biology
Serpins
Retinal neovascularization
Proteins
Retinal
Cell Biology
Blotting
Northern
eye diseases
Rats
Disease Models
Animal
Nerve growth factor
Animals
Newborn
Gene Expression Regulation
chemistry
Cancer research
RNA
sense organs
Zdroj: FEBS Letters. 489:270-276
ISSN: 0014-5793
Popis: Retinal levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF), an angiogenic inhibitor, were measured and correlated with the ischemia-induced retinal neovascularization in rats. The retinas with neovascularization showed a 5-fold increase in VEGF while 2-fold decrease in PEDF, compared to the age-matched controls, resulting in an increased VEGF/PEDF ratio. The time course of the VEGF/PEDF ratio change correlated with the progression of retinal neovascularization. Changes in the VEGF and PEDF mRNAs preceded their protein level changes. These results suggest that an unbalance between angiogenic stimulators and inhibitors may contribute to retinal neovascularization.
Databáze: OpenAIRE
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