Iridium-catalyzed alkenyl C–H allylation using conjugated dienes
| Autor: | Tingyan Li, Yan Jiang, Jian Zhang, Xiunan Lu, Yaling Sun, Liangyao Xu, Keke Meng, Guofu Zhong |
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| Rok vydání: | 2019 |
| Předmět: |
010405 organic chemistry
Chemistry Ligand Metals and Alloys chemistry.chemical_element General Chemistry Conjugated system 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Hydrolysis chemistry.chemical_compound Amide Materials Chemistry Ceramics and Composites Surface modification Iridium |
| Zdroj: | Chemical Communications. 55:9757-9760 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/c9cc04419a |
| Popis: | An iridium-catalyzed C-H allylation of acrylamides with conjugated dienes was developed, using NH-Ts amide as the directing group. The ligand- and additive-free protocol provided a convenient and atom economic synthesis of branched 1,4-diene skeletons, enabling the tolerance of a wide scope of functionalities such as OMe, F, Cl, Br and CF3. The utility of this protocol is also demonstrated by a preparative scale, as well as C-H functionalization of artemisic amide. Furthermore, NH-Ts amide was efficiently removed by methylation and hydrolysis procedures to provide 1,4-dienoic acid. |
| Databáze: | OpenAIRE |
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