Histone Modifications in Stem Cell Development and Their Clinical Implications
| Autor: | Axel Imhof, Moritz Völker-Albert, Stefan Holdenrieder, Abel Jacobus Bronkhorst |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pluripotent Stem Cells
0301 basic medicine Cell type Review Biology Biochemistry Epigenesis Genetic Histones 03 medical and health sciences 0302 clinical medicine stem cells Cancer stem cell Genetics Humans Epigenetics epigenetics histone modifications Cell Differentiation Cell Biology Cell cycle Chromatin Cell biology 030104 developmental biology Histone Cell culture biology.protein cell cycle Stem cell Protein Processing Post-Translational metabolism 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Stem Cell Reports |
| ISSN: | 2213-6711 |
| Popis: | Human stem cells bear a great potential for multiple therapeutic applications but at the same time constitute a major threat to human health in the form of cancer stem cells. The molecular processes that govern stem cell maintenance or differentiation have been extensively studied in model organisms or cell culture, but it has been difficult to extrapolate these insights to therapeutic applications. Recent advances in the field suggest that local and global changes in histone modifications that affect chromatin structure could influence the capability of cells to either maintain their stem cell identity or differentiate into specialized cell types. The enzymes that regulate these modifications are therefore among the prime targets for potential drugs that can influence and potentially improve the therapeutic application of stem cells. In this review, we discuss recent findings on the role of histone modifications in stem cell regulation and their potential implications for clinical applications. In this article, Axel Imhof and colleagues discuss recent findings on the role of histone modifications in stem cell regulation. In particular, this article focuses on the effects of global processes such as the cell cycle or the metabolic state on chromatin maturation and links them to targeted therapeutic interventions aiming to reset the epigenetic landscape. |
| Databáze: | OpenAIRE |
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