A dietary intervention to improve the microbiome composition of pregnant women with Crohn's disease and their offspring: The MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial design
| Autor: | Joana Torres, Jianzhong Hu, Shauna Simpson, Joanne Stone, Barbara C. Olendzki, Marla Dubinsky, Jose C. Clemente, Caroline Eisele, Christine F. Frisard, Inga Peter, Jean-Frederic Colombel, Alexa Rendon, Sierra R. White, Ana Maldonado-Contreras, Anketse Debebe, Leonid Tarassishin, Kelly Hawkins, Nilendra Nair, João Sabino, Caitlin Cawley |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Chronic condition
Offspring IBD-AID™ IBD Anti-inflammatory Diet Disease Gut flora Research & Experimental Medicine Inflammatory bowel disease Article 03 medical and health sciences 0302 clinical medicine FECAL CALPROTECTIN Pregnancy MANAGEMENT Medicine 030212 general & internal medicine Microbiome IBD-AID (TM) EXCLUSIVE ENTERAL NUTRITION Pharmacology RISK Crohn's disease lcsh:R5-920 Science & Technology biology IBD inflammatory bowel disease business.industry GUT MICROBIOTA General Medicine RECALL biology.organism_classification medicine.disease digestive system diseases Diet MUCOSAL Medicine Research & Experimental IBD-AID™ Immunology MELODY Modulating Early Life Microbiome through Dietary Intervention in Pregnancy FUNCTIONAL GASTROINTESTINAL SYMPTOMS CD Crohn's disease business lcsh:Medicine (General) Life Sciences & Biomedicine 030217 neurology & neurosurgery INFLAMMATORY-BOWEL-DISEASE CESAREAN-SECTION |
| Zdroj: | Contemporary Clinical Trials Communications Contemporary Clinical Trials Communications, Vol 18, Iss, Pp 100573-(2020) |
| ISSN: | 2451-8654 |
| Popis: | Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic condition of the gastrointestinal tract that is caused by the loss of mucosal tolerance towards the commensal bacteria resulting in inflammatory responses. It has long been postulated that the gut microbiota, a complex and dynamic population of microorganisms, plays a key role in the pathogenesis of IBD. Maternal diagnosis of IBD has been identified as the greatest risk factor for IBD in offspring increasing the odds of developing the disease >4.5-fold. Moreover, babies born to mothers with IBD have demonstrated reduced gut bacterial diversity. There is accumulating evidence that the early life microbiota colonization is informed by maternal diet within the 3rd trimester of pregnancy. While babies born to mothers with IBD would pose an ideal cohort for intervention, no primary prevention measures are currently available. Therefore, we designed the MELODY (Modulating Early Life Microbiome through Dietary Intervention in Pregnancy) trial to test whether the IBD-AID™ dietary intervention during the last trimester of pregnancy can beneficially shift the microbiome of CD patients and their babies, thereby promoting a strong, effective immune system during a critical time of the immune system development. We will also test if favorable changes in the microbiome can lead to a reduced risk of postpartum CD relapse and lower mucosal inflammation in the offspring. This study will help create new opportunities to foster a healthy microbiome in the offspring at high risk of other immune-mediated diseases, potentially reducing their risk later in life. ispartof: CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS vol:18 ispartof: location:Netherlands status: published |
| Databáze: | OpenAIRE |
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