Chlorogenic Acid and Mental Diseases: From Chemistry to Medicine
Autor: | Nady Braidy, Antoni Sureda, Azadeh Manayi, Seyed Mohammad Nabavi, Olga Gortzi, William N. Setzer, Maria Daglia, Seyed Fazel Nabavi, Silvia Tejada |
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Přispěvatelé: | Nabavi Seyed, Fazel, Tejada, Silvia, Setzer William, N, Gortzi, Olga, Sureda, Antoni, Braidy, Nady, Daglia, Maria, Manayi, Azadeh, Nabavi Seyed, Mohammad |
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Antioxidant polyphenolic medicine.medical_treatment chlorogenic acid Neuroprotection Article Antioxidants 03 medical and health sciences chemistry.chemical_compound Human health 0302 clinical medicine Chlorogenic acid Web of knowledge medicine oxidative stress Animals Humans Pharmacology (medical) Beneficial effects Pharmacology Traditional medicine business.industry neuroprotective General Medicine Psychiatry and Mental health 030104 developmental biology Neuroprotective Agents Neurology chemistry Biochemistry Psychotic Disorders Polyphenol inflammation Neurology (clinical) business 030217 neurology & neurosurgery Olive oil |
Zdroj: | Current Neuropharmacology |
ISSN: | 1875-6190 1570-159X |
Popis: | Background At present, much attention has been focused on the beneficial effects of natural products on the human health due to their high efficacy and low adverse effects. Among them, polyphenolic compounds are known as one of the most important and common classes of natural products, which possess multiple range of health-promotion effects including anti-inflammatory and antioxidant activities. A plethora of scientific evidence has shown that polyphenolic compounds possess beneficial effects on the central nervous system. Methods Data were collected from Web of Science (ISI Web of Knowledge), Medline, Pubmed, Scopus, Embase, and BIOSIS Previews (from 1950 to 2015), through searching of these keywords: "chlorogenic acid and mental diseases" and "chlorogenic acid and neuroprotection". Results Chlorogenic acid is known as one of the most common polyphenolic compounds, and is found in different types of fruits and vegetables, spices, wine, olive oil, as well as coffee. The potential neuroprotective effects of chlorogenic acid have been highlighted in several in vitro and in vivo studies. This review critically analyses the available scientific evidence regarding the neuroprotective effects of chlorogenic acid, and its neuropharmacological mechanisms of action. In addition, we also discuss its biosynthesis, sources, bioavailability and metabolism, to provide a broad perspective of the therapeutic implications of this compound in brain health and disease. Conclusion The present review showed that chlorogenic acid possesses neuroprotective effects under the both in vitro and in vivo models. |
Databáze: | OpenAIRE |
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