Fucus vesiculosus and Ascophyllum nodosum Ameliorate Liver Function by Reducing Diet-Induced Steatosis in Rats
| Autor: | Nicola Ferri, Samantha Sarcognato, Daniela Gabbia, Maria Guido, Miriam Saponaro, Maria Carrara, Sara De Martin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Pharmaceutical Science Fucus vesiculosus Article 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine NAFLD insulin resistance Drug Discovery Nonalcoholic fatty liver disease medicine blood glucose Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 030304 developmental biology Glycemic 0303 health sciences biology business.industry Ascophyllum nodosum brown seaweeds fucus vesiculosus medicine.disease biology.organism_classification Endocrinology Postprandial lcsh:Biology (General) 030220 oncology & carcinogenesis ascophyllum nodosum Liver function Steatosis Metabolic syndrome business |
| Zdroj: | Marine Drugs Marine Drugs, Vol 18, Iss 1, p 62 (2020) Volume 18 Issue 1 |
| Popis: | The Asian coastal communities have used the brown seaweeds Fucus vesiculosus and Ascophyllum nodosum since ancient times. Recently, some in vitro and in vivo studies have demonstrated their abilities in reducing risk factors for metabolic syndrome. Here, we analyzed the protective effect of a phytocomplex extracted from these seaweeds on the deposition of fat in the liver after the administration of a high-fat diet (HFD) to rats for five weeks. The administration of F. vesiculosus and A. nodosum led to significant reductions in microvescicular steatosis and plasma biochemical and lipid parameters, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total and conjugated bilirubin, and triglycerides. Furthermore, the postprandial glycemic peak was delayed and significantly reduced (p < 0.01) by the algal extract administration. In conclusion, this extract is effective in reducing microvescicular steatosis and improving glycemic control, thereby lowering the risk of nonalcoholic fatty liver disease, obesity, and diabetes, diseases related to the consumption of fat and sugar-enriched diets. |
| Databáze: | OpenAIRE |
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