In VivoEvaluation of the Antioxidant Activity and Protective Action of the SeaweedGracilaria birdiae
| Autor: | Joanna Angelis Costa Barros-Gomes, Hugo Alexandre Oliveira Rocha, Rafael Barros Gomes Camara, Daiany Laise Araújo Nascimento, Rayanne Kelly Silva, Karoline Rachel Teodosio Melo, Dayane Lopes Gomes, Ana Cristina Rodrigues Silveira, Jailma Almeida-Lima, Naisandra Bezerra da Silva |
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| Rok vydání: | 2018 |
| Předmět: |
Aging
Antioxidant Article Subject medicine.medical_treatment Glutathione reductase Trolox equivalent antioxidant capacity CCL4 Biochemistry chemistry.chemical_compound 0404 agricultural biotechnology In vivo medicine Animals Food science lcsh:QH573-671 Antioxidants pharmacology chemistry.chemical_classification biology Gracilaria birdiae lcsh:Cytology 04 agricultural and veterinary sciences Cell Biology General Medicine 040401 food science Enzyme chemistry Catalase biology.protein Carbon tetrachloride Research Article |
| Zdroj: | Oxidative Medicine and Cellular Longevity, Vol 2018 (2018) Oxidative Medicine and Cellular Longevity Repositório Institucional da UFRN Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
| ISSN: | 1942-0994 1942-0900 |
| DOI: | 10.1155/2018/9354296 |
| Popis: | The red seaweedGracilaria birdiae(GB) is farmed and used as food in northeast Brazil. However, the economic potential of this seaweed has been explored little. To enable direct consumption and/or product diversification from GB, it is necessary to evaluate its effectin vivo. In this study, the food of mice was improved with the addition ofGB. After 21 days, the consumption of seaweed reduced the weight gain and blood glucose levels in mice. In addition, it increased the trolox equivalent antioxidant capacity and glutathione reductase and catalase levels compared to those of the control group. In addition, some mice also received carbon tetrachloride (CCl4). In this case, histological, enzymatic, and antioxidant tests showed that the seaweed could protect animals from damage caused by this toxic agent. In addition, GB aqueous extract (AE) inhibited 50% of 3T3-L1 cell differentiation into adipocytes, whereas GB ethanolic extract was not effective. AE is composed mainly of sulfated polysaccharides. The results of the present study indicate that the alga GB protected the mice from CCl4-induced damage, indicating that the seaweed exhibits protective actionin vivo. In addition, GB decreased the animal weight gain, which was mainly due to the action of the sulfated polysaccharides synthesized by this seaweed. |
| Databáze: | OpenAIRE |
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