Plasma concentrations and hemodynamic effects of intravenous, sublingual, and aerosolized nitroglycerin in patients undergoing cardiac catheterization
| Autor: | Stephen H. Curry, Robert K. Stack, Larry M. Lopez, Charles R. Lambert, Hae-Ryun Kwon |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Cardiac Catheterization medicine.medical_treatment Administration Sublingual Pharmaceutical Science Hemodynamics Coronary artery disease Nitroglycerin Administration Inhalation Heart rate Humans Medicine Pharmacology (medical) cardiovascular diseases Aerosolization Cardiac catheterization Aerosols Pharmacology business.industry General Medicine medicine.disease Preload Blood pressure Anesthesia Injections Intravenous cardiovascular system business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Biopharmaceutics & Drug Disposition. 14:107-118 |
| ISSN: | 1099-081X 0142-2782 |
| DOI: | 10.1002/bdd.2510140203 |
| Popis: | Intravenous, sublingual, or aerosolized nitroglycerin was administered to 19 patients with coronary artery disease during clinically indicated cardiac catheterization. Eight blood samples were collected over 15 min from each patient, and analyzed for content of nitroglycerin, 1,2-glycerol dinitrate, and 1,3-glycerol dinitrate. Simultaneously, heart rate (HR), systolic blood pressure (SBP), and left ventricular end-diastolic pressure (LVEDP) were recorded. Plasma concentrations of nitroglycerin were highest after intravenous injection and lowest after sublingual tablets. Metabolite concentrations were highest after intravenous injection at early time-points; at later time-points, no between-group differences could be detected. SBP was minimally affected by intravenous nitroglycerin but was significantly reduced by sublingual and aerosolized formulations. Minor fluctuations in HR were observed in association with all three formulations. LVEDP was reduced by all three formulations of nitroglycerin but most rapidly by the intravenous form. Overall, no differences were detected in hemodynamic responses caused by sublingual and aerosolized nitroglycerin. Efficacy of sublingual and aerosolized nitroglycerin in patients undergoing cardiac catheterization is equivalent. |
| Databáze: | OpenAIRE |
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