Clinical Factors Associated with COVID-19 Severity in Mexican Patients: Cross-Sectional Analysis from a Multicentric Hospital Study
| Autor: | Julio Enrique Castañeda-Delgado, Carolina Ivette Zubía-Nevárez, Lorena Reyes-Silva, Joel Monárrez-Espino, Ana Sofía Herrera van-Oostdam, Yamilé López-Hernández, Juan Pablo Castillo-Palencia |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
myalgia
medicine.medical_specialty Multivariate analysis Leadership and Management Cross-sectional study Health Informatics 030204 cardiovascular system & hematology Article Odds 03 medical and health sciences 0302 clinical medicine Health Information Management Internal medicine Diabetes mellitus Medicine 030212 general & internal medicine Mexico business.industry Health Policy COVID-19 Odds ratio medicine.disease Obesity Dysgeusia signs and symptoms multivariate analysis disease severity medicine.symptom business |
| Zdroj: | Healthcare Healthcare, Vol 9, Iss 895, p 895 (2021) Volume 9 Issue 7 |
| ISSN: | 2227-9032 |
| Popis: | (1) Background: Latin America has been harshly hit by SARS-CoV-2, but reporting from this region is still incomplete. This study aimed at identifying and comparing clinical characteristics of patients with COVID-19 at different stages of disease severity. (2) Methods: Cross-sectional multicentric study. Individuals with nasopharyngeal PCR were categorized into four groups: (1) negative, (2) positive, not hospitalized, (3) positive, hospitalized with/without supplementary oxygen, and (4) positive, intubated. Clinical and laboratory data were compared, using group 1 as the reference. Multivariate multinomial logistic regression was used to compare adjusted odds ratios. (3) Results: Nine variables remained in the model, explaining 76% of the variability. Men had increased odds, from 1.90 (95%CI 0.87–4.15) in the comparison of 2 vs. 1, to 3.66 (1.12–11.9) in 4 vs. 1. Diabetes and obesity were strong predictors. For diabetes, the odds for groups 2, 3, and 4 were 1.56 (0.29–8.16), 12.8 (2.50–65.8), and 16.1 (2.87–90.2) for obesity, these were 0.79 (0.31–2.05), 3.38 (1.04–10.9), and 4.10 (1.16–14.4), respectively. Fever, myalgia/arthralgia, cough, dyspnea, and neutrophilia were associated with the more severe COVID-19 group. Anosmia/dysgeusia were more likely to occur in group 2 (25.5 2.51–259). (4) Conclusion: The results point to relevant differences in clinical and laboratory features of COVID-19 by level of severity that can be used in medical practice. |
| Databáze: | OpenAIRE |
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