Leufolins A and B, potent butyrylcholinesterase-inhibiting flavonoid glucosides from Leucas urticifolia
| Autor: | Abdul Malik, Lubna Iqbal, Sher Bahadar Khan, Mehreen Latif, Atia-tun-Noor, Nighat Afza, Itrat Fatima, Ijaz Ahmad |
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| Rok vydání: | 2007 |
| Předmět: |
Family Lamiaceae
Magnetic Resonance Spectroscopy Stereochemistry Flavonoid Pharmaceutical Science Analytical Chemistry lcsh:QD241-441 lcsh:Organic chemistry Glucosides Drug Discovery Physical and Theoretical Chemistry Spectral data Leucas chemistry.chemical_classification Flavonoids Carbon Isotopes Lamiaceae Inhibitory potential Amaranthaceae biology Full Paper Leucas urticifolia Organic Chemistry Inhibitory activity Leufolin B biology.organism_classification Leufolin A chemistry Butyrylcholinesterase Chemistry (miscellaneous) Molecular Medicine Cholinesterase Inhibitors Protons |
| Zdroj: | ResearcherID Molecules, Vol 12, Iss 7, Pp 1447-1454 (2007) Molecules; Volume 12; Issue 7; Pages: 1447-1454 |
| ISSN: | 1420-3049 |
| Popis: | New flavonoidal glucosides leufolins A ( 1 ) and B ( 2 ), have been isolated from the ethyl acetate soluble fraction of the whole plants of Leucas urticifolia . Their structures were elucidated on the basis of extensive analysis of nuclear magnetic resonance (1D and 2D NMR) spectral data. Both of these compounds exhiited significant inhibitory potential against the enzyme butyrylcholinesterase. Keywords: Leucas urticifolia, Lamiaceae, Leufolin A, Leufolin B, Butyrylcholinesterase, Inhibitory activity __________________________________________________________________________________ Introduction The genus Leucas , belonging to the family Lamiaceae, comprises about 100 species. In the Indo-Pakistani subcontinent, the genus is represented by 35 species which are mostly herbs or undershrubs found in temperate or hilly regions [1]. L. urticifolia is an annual herb which is commonly found in Karachi and other parts of Sind province of Pakistan. It is astringent, stimulant, haemostatic |
| Databáze: | OpenAIRE |
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