Frontal lobe shortening in second-trimester fetuses with trisomy 21: usefulness as a US marker
| Autor: | Laurence E. Shields, H V Nghiem, Edith Cheng, Stefanie B. Uhrich, Justin A. Reichman, Thomas C. Winter, Cathy A. Komarniski, Joseph A. Luna, Ann M. Doll, Udo P. Schmiedl |
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| Rok vydání: | 1998 |
| Předmět: |
Down syndrome
Population Aneuploidy Gestational Age Sensitivity and Specificity Ultrasonography Prenatal Pregnancy mental disorders Humans Medicine Radiology Nuclear Medicine and imaging education Fetus education.field_of_study business.industry Gestational age Anatomy medicine.disease Frontal Lobe Frontal bone ROC Curve Frontal lobe Pregnancy Trimester Second Female Down Syndrome business Trisomy |
| Zdroj: | Radiology. 207:215-222 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.207.1.9530318 |
| Popis: | To determine whether the frontal lobe is disproportionately smaller than normal in second-trimester fetuses with Down syndrome by using prenatal ultrasonographic (US) measurements of the frontothalamic distance (FTD).The FTD, measured from the inner table of the frontal bone to the posterior margin of the thalamus, was measured in 43 fetuses (mean gestational age, 17.2 weeks +/- 1.3 [standard deviation]; range, 15.0-20.4 weeks) with chromosomally proved trisomy 21 and in 160 chromosomally normal fetuses (mean gestational age, 17.1 weeks +/- 1.5; range, 14.5-22.5 weeks). Other cranial biometric ratios also were calculated.The FTD was best predicted from the estimated gestational age (EGA) in the euploid population with the quadratic equation FTD = -0.0120 x EGA2 + 0.6917 x EGA - 5.2349 (R2 = .731) or from the biparietal diameter (BPD) with the linear equation FTD = 0.6837 x BPD + 0.5525 (R2 = .731). If an observed-to-expected ratio of 0.84 is used as a cutoff sign to screen for trisomy 21, a sensitivity of 16%, specificity of 97%, odds ratio of 6.03 (95% confidence interval, 1.81, 20.1), and relative risk of 5.98 are achieved.The frontal lobe is statistically significantly smaller in fetuses with trisomy 21. US measurement of the FTD may prove to be a useful adjunctive screening tool if used with other markers for Down syndrome. |
| Databáze: | OpenAIRE |
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