The biology and therapeutic potential of natural regulatory T-cells in the bone marrow transplant setting

Autor:	Timothy P. Moran, James M. Coghill, Michael J. Carlson, Jonathan S. Serody
Rok vydání:	2008
Předmět:	Cancer Research Adoptive cell transfer Bone marrow transplant Graft vs Host Disease chemical and pharmacologic phenomena Disease Malignancy T-Lymphocytes Regulatory Mice Secondary Prevention Animals Humans Medicine Bone Marrow Transplantation business.industry Hematology medicine.disease Outcome parameter Transplantation Haematopoiesis surgical procedures operative Graft-versus-host disease Oncology Hematologic Neoplasms Immunology business
Zdroj:	Leukemia & Lymphoma. 49:1860-1869
ISSN:	1029-2403 1042-8194
DOI:	10.1080/10428190802272684
Popis:	Graft-versus-host disease (GVHD) remains a major barrier to the long-term success of allogeneic hematopoietic stem-cell transplantation for hematologic malignancies. This has prompted a great deal of interest in the development of alternative GVHD management strategies such as the adoptive transfer of lymphocytes with immunosuppressant activity. This review will focus on the biology of thymically derived regulatory T-cells (Tregs) and their potential therapeutic role in human bone marrow transplantation. A discussion of their basic suppressive mechanisms and in vivo trafficking patterns will be presented, along with an overview of important preclinical studies using murine GVHD/tumor models. Currently available clinical data will also be discussed, including the contribution of Tregs to various transplant outcome parameters such as GVHD incidence and malignancy relapse rates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719c672df2df6ce68ab317f4bf7468c0 https://doi.org/10.1080/10428190802272684 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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