Hyperaemia in rat neocortex produced by acute exposure to methylenedioxymethamphetamine
| Autor: | Isobel M. Ritchie, E. M. Dickson, B. Kelly, M. J. A. Cursham, M. C. Stevens, Paul A.T. Kelly, M. J. Reidy, Meharpal Sangra, F. P. Neilson |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Time Factors N-Methyl-3 4-methylenedioxyamphetamine Central nervous system Hemodynamics Hippocampus Blood Pressure Hyperemia Striatum Motor Activity Rats Sprague-Dawley Hyperaemia Internal medicine medicine Animals Tissue Distribution Molecular Biology Cerebral Cortex Neocortex Chemistry General Neuroscience Brain Rats Endocrinology medicine.anatomical_structure Glucose Cerebral blood flow Cerebral cortex Anesthesia Cerebrovascular Circulation Neurology (clinical) medicine.symptom Developmental Biology |
| Zdroj: | Brain research. 665(2) |
| ISSN: | 0006-8993 |
| Popis: | Cerebral blood flow and glucose utilization were measured in rat neocortex, hippocampus and striatum following methylenedioxymethamphetamine injection (5 mg/kg, i.v.), using the tracers [14C]iodoantipyrine and [14C]2-deoxyglucose, respectively. In control rats, blood flow was coupled to glucose metabolism, but in methylenedioxymethamphetamine-treated rats, marked hyperperfusion was measured in frontal and parietal cortex with no change in glucose use. This suggests that methylenedioxymethamphetamine has the potential to disrupt cerebrovascular control. |
| Databáze: | OpenAIRE |
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