The majority of MRSA colonized children not given eradication treatment are still colonized one year later. Systemic antibiotics improve the eradication rate

Autor: Ann Cathrine Petersson, Anna Nilsson, Jimmy Jörgensen, Fredrik Månsson, Håkan Janson
Rok vydání: 2018
Předmět:
0301 basic medicine
Microbiology (medical)
Male
Methicillin-Resistant Staphylococcus aureus
medicine.medical_specialty
Adolescent
030106 microbiology
medicine.disease_cause
Staphylococcal infections
Asymptomatic
03 medical and health sciences
Risk Factors
Throat
Internal medicine
Medicine
Humans
Colonization
Child
Sweden
Family Characteristics
General Immunology and Microbiology
Transmission (medicine)
business.industry
Pharynx
Infant
Newborn
Infant
General Medicine
biochemical phenomena
metabolism
and nutrition
Staphylococcal Infections
medicine.disease
bacterial infections and mycoses
Methicillin-resistant Staphylococcus aureus
Anti-Bacterial Agents
Infectious Diseases
medicine.anatomical_structure
Treatment Outcome
Staphylococcus aureus
Child
Preschool
Carrier State
Female
medicine.symptom
business
Follow-Up Studies
Zdroj: Infectious diseases (London, England). 50(9)
ISSN: 2374-4243
Popis: Background: Colonization with methicillin-resistant Staphylococcus aureus (MRSA) can cause endogenously derived infections and be a source of transmission to other people. Neither colonization time of asymptomatic MRSA colonization nor the effect of treatment aiming at MRSA eradication in children has been thoroughly investigated. Methods: Two hundred ninety-three children spa-type were evaluated in a majority of cases. The sampling was repeated approximately every 6 month after initial detection. When three consecutive sets of negative samples during at least a 6-month period were obtained, the MRSA was considered permanently eradicated. MRSA eradication treatment given, on clinical grounds during follow-up, was noted. Results: One year after detection 62% of the untreated children were still MRSA positive and after 2 years 28%. MRSA throat colonization and having MRSA positive household contacts significantly prolonged the observed colonization time. Topical MRSA eradication treatment was successful in 36% of cases and in 65% if systemic antibiotics were added. Presence of PVL correlated with shorter observed colonization time in the older age group and with increased eradication success among throat carriers. Conclusion: MRSA throat colonization and having MRSA positive household contacts prolongs the time of MRSA colonization in children. Systemic antibiotics enhance the effect of MRSA eradication treatment.
Databáze: OpenAIRE
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