Distinct Profiles of Gastritis in Dyspepsia Subgroups: Their Different Clinical Responses to Gastritis Healing afterHelicobacter pyloriEradication
| Autor: | E. Trespi, Ombretta Luinetti, Laura Villani, Enrico Solcia, F. Broglia, Roberto Fiocca |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Gastroenterology Helicobacter Infections Sex Factors Internal medicine Biopsy Prevalence Humans Medicine Dyspepsia Omeprazole Helicobacter pylori biology medicine.diagnostic_test business.industry Incidence Age Factors Amoxicillin Middle Aged biology.organism_classification digestive system diseases Gastric Mucosa Gastritis Chronic Disease Helicobacter pylori gastritis Drug Therapy Combination Female medicine.symptom business medicine.drug |
| Zdroj: | Scandinavian Journal of Gastroenterology. 29:884-888 |
| ISSN: | 1502-7708 0036-5521 |
| Popis: | A contribution of Helicobacter pylori gastritis to the pathogenesis of non-ulcer dyspepsia (NUD) remains uncertain.Administration of an appropriate clinical questionnaire followed by endoscopy allowed us to select, among 139 outpatients with dyspepsia, 87 non-ulcer dyspepsia patients with more severe and group-distinctive symptoms, 35 of whom were classified as having ulcer-like (ULD). 38 as dysmotility-like (DLD), and 14 as reflux-like dyspepsia (RLD). Biopsy specimens were evaluated for H. pylori gastritis in accordance with the Sydney system. The 70 H. pylori-positive cases were treated with omeprazole, 20 mg twice daily, and amoxycillin, 1 g three times daily for 2 weeks.Higher rates of H. pylori colonization were found histologically in the gastric mucosa of ULD (91%) and RLD (86%) than in that of DLD (68%) or asymptomatic (42%) patients. ULD differed from RLD patients in their higher score of antritis activity. Three and 6 months after H. pylori eradication ULD (but not DLD) showed significant regression of dypspetic symptoms scores.It seems likely that H. pylori gastritis, with special reference to active antritis, is among causative factors of ULD. Its role in the pathogenesis of RLD and DLD needs further investigation. |
| Databáze: | OpenAIRE |
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