Erythropoietin as Treatment for Late Hyporegenerative Anemia in Neonates with Rh Hemolytic Disease after in utero Exchange Transfusion
| Autor: | Cécile Chau, Claire Nicaise, Claude D'Ercole, Catherine Gire, Christian Palix, Paul Casha |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Hemolytic anemia Embryology medicine.medical_specialty Blood transfusion Anemia medicine.medical_treatment Exchange Transfusion Whole Blood Blood Transfusion Intrauterine Exchange transfusion Rh Isoimmunization Gastroenterology Intravenous Immunoglobulin Therapy Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Erythropoietin Whole blood business.industry Infant Newborn Anemia Aplastic Obstetrics and Gynecology General Medicine medicine.disease Recombinant Proteins Surgery In utero Pediatrics Perinatology and Child Health business medicine.drug |
| Zdroj: | Fetal Diagnosis and Therapy. 17:22-24 |
| ISSN: | 1421-9964 1015-3837 |
| DOI: | 10.1159/000048000 |
| Popis: | We report the effects of recombinant human erythropoietin (rHuEPO) in the treatment of late hyporegenerative anemia in 2 neonates with Rh hemolytic disease who had received several in utero exchange transfusions. In both cases anemia occurred at 6 weeks of age and we started therapy at approximately 70 days of age. We used rHuEPO at 250 U/kg three times a week. We also used high-dose intravenous immunoglobulin therapy. One week after initiation of erythropoietin treatment, an increase in reticulocyte count and Hb level was noted in our 2 patients. They did not require further erythrocyte transfusions but they already had received two transfusions after birth. There were no side effects attributable to rHuEPO treatment. |
| Databáze: | OpenAIRE |
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