Preoperative Interleukin-22 Values Add Valuable Information for Outcome Prediction Following Orthotopic Liver Transplantation: A Preliminary Study
| Autor: | Bertram Scheller, Tobias M. Bingold, Peter Rosenberger, Gordon Pipa, Patrick Paulus, Lara Just, Wolf O. Bechstein, Kai Zacharowski, Heiko Mühl, Heimo Wissing, Colleen Cuca, Christian Mönch |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Orthotopic liver transplantation medicine.medical_treatment Kaplan-Meier Estimate Liver transplantation Gastroenterology Procalcitonin End Stage Liver Disease Interleukin 22 Liver disease Germany Internal medicine Humans Medicine ddc:610 Aged Transplantation Interleukin-6 business.industry Interleukins Interleukin General Medicine Length of Stay Middle Aged Prognosis medicine.disease Liver Transplantation Surgery C-Reactive Protein Treatment Outcome Preoperative Period Linear Models Cytokines Female business Outcome prediction Biomarkers |
| Zdroj: | Annals of Transplantation. 19:503-512 |
| ISSN: | 2329-0358 |
| Popis: | BACKGROUND: Recent findings support the idea that interleukin (IL)-22 serum levels are related to disease severity in end-stage liver disease. Existing scoring systems--Model for End-Stage Liver Disease (MELD), Survival Outcomes Following Liver Transplantation (SOFT) and Pre-allocation-SOFT (P-SOFT)--are well-established in appraising survival rates with or without liver transplantation. We tested the hypothesis that IL-22 serum levels at transplantation date correlate with survival and potentially have value as a predictive factor for survival. MATERIAL AND METHODS: MELD, SOFT, and P-SOFT scores were calculated to estimate post-transplantation survival. Serum levels of IL-22, IL-6, IL-10, C-reactive protein (CRP), and procalcitonin (PCT) were collected prior to transplantation in 41 patients. Outcomes were assessed at 3 months, 1 year, and 3 years after transplantation. RESULTS: IL-22 significantly correlated with MELD, P-SOFT, and SOFT scores (Rs 0.35, 0.63, 0.56 respectively, p |
| Databáze: | OpenAIRE |
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