Biphasic Effects of Blue Light Irradiation on Human Umbilical Vein Endothelial Cells
| Autor: | Nuh N. Rahbari, Carsten Sticht, Marielle Bouschbacher, Kejia Kan, Yifei Mu, Martin Sigl, Norbert Gretz, Prama Pallavi, Michael Keese, Natalia Kuch |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Programmed cell death Angiogenesis QH301-705.5 Necroptosis Cell Medicine (miscellaneous) General Biochemistry Genetics and Molecular Biology Umbilical vein Article 03 medical and health sciences angiogenesis 0302 clinical medicine VEGF Signaling Pathway photobiomodulation medicine Viability assay Biology (General) reactive oxygen species Chemistry apoptosis blue light Cell biology Endothelial stem cell 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis endothelial cell |
| Zdroj: | Biomedicines, Vol 9, Iss 829, p 829 (2021) Biomedicines Volume 9 Issue 7 |
| ISSN: | 2227-9059 |
| Popis: | Blue light regulates biological function in various cells, such as proliferation, oxidative stress, and cell death. We employed blue light illumination on human umbilical vein endothelial cells utilizing a LED device at 453 nm wavelength and revealed a novel biphasic response on human umbilical vein endothelial cells (HUVECs). The results showed that low fluence blue light irradiation promoted the fundamental cell activities, including cell viability, migration and angiogenesis by activating the angiogenic pathways such as the VEGF signaling pathway. In contrast, high fluence illumination caused the opposite effect on those activities by upregulating pro-apoptotic signaling cascades like ferroptosis, necroptosis and the p53 signaling pathways. Our results provide an underlying insight into photobiomodulation by blue light and may help to implement potential treatment strategies for treating angiogenesis-dependent diseases. |
| Databáze: | OpenAIRE |
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