Long-term impact of complications after lung resections in non-small cell lung cancer
| Autor: | Makoto Nakagawa, Masakazu Sugaya, Shuichi Shinohara, Kenichi Kobayashi, Masaki Matsuo, Chinatsu Kasahara, Takamitsu Onitsuka |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty business.industry Proportional hazards model Hazard ratio Pulmonary Complication non-small cell lung cancer (NSCLC) Retrospective cohort study medicine.disease Confidence interval Surgery 03 medical and health sciences 0302 clinical medicine 030228 respiratory system 030220 oncology & carcinogenesis Medicine Original Article business Complication Lung cancer |
| Zdroj: | Journal of Thoracic Disease. 11:2024-2033 |
| ISSN: | 2077-6624 2072-1439 |
| DOI: | 10.21037/jtd.2019.04.91 |
| Popis: | BACKGROUND: Postoperative complications after lung resection are common and fatal. The immediate effects of postoperative complications are related to poor prognosis; however, the long-term effects have not been assessed. Thus, this investigation aimed to clarify the long-term effects of postoperative complications among patients with resected non-small cell lung cancer (NSCLC). METHODS: This retrospective cohort study included 345 patients with resected NSCLC from a single institution. We used the Clavien-Dindo classification to classify postoperative complications. Postoperative complications were defined as complications with a Clavien-Dindo grade of ≥2. The Kaplan-Meier method was used to evaluate survival. Prognostic factors were analyzed using a Cox proportional hazard model. RESULTS: There were 110 patients with postoperative complications (31.9%). The 5-year overall survival (OS), recurrence-free survival (RFS), and cause-specific survival (CSS) rates were significantly lower in patients with complications than in those without complications [OS: 66.1%, 95% confidence interval (CI): 55.4–74.8% vs. 78.0%, 95% CI: 71.8–83.1%, P=0.001; RFS: 48.8%, 95% CI: 38.1–58.7% vs. 70.8%, 95% CI: 64.2–76.4%, P |
| Databáze: | OpenAIRE |
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