Pharmacokinetics of florfenicol following intravenous and intramuscular doses to cattle
| Autor: | S. M. Ashcraft, Diane F. Gerken, Richard A. Sams, R. D. Lobell, J C Johnson, K.J. Varma |
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| Rok vydání: | 1994 |
| Předmět: |
Florfenicol
Male medicine.drug_class Antibiotics Serum protein Biological Availability Pharmacology Injections Intramuscular chemistry.chemical_compound Pharmacokinetics medicine Animals Chromatography High Pressure Liquid Volume of distribution Thiamphenicol General Veterinary business.industry Half-life Total body Blood Proteins Anti-Bacterial Agents chemistry Injections Intravenous Cattle Female Intramuscular injection business Half-Life |
| Zdroj: | Journal of veterinary pharmacology and therapeutics. 17(4) |
| ISSN: | 0140-7783 |
| Popis: | The disposition of florfenicol after single intravenous and intramuscular doses of 20 mg of florfenicol/kg of body weight (b.w.) to feeder calves was investigated. Serum florfenicol concentrations were determined by a sensitive high performance liquid chromatographic method with a limit of quantitation of 0.025 microgram/ml. The extent of serum protein binding of florfenicol was only 13.2% at a serum florfenicol concentration of 3.0 micrograms/ml. Serum concentration-time data after intravenous administration were best described by a triexponential equation. Total body clearance and steady state volume of distribution were 3.75 ml/min/kg b.w. and 761 ml/kg b.w., respectively. The terminal half-life after intravenous administration was 159 min. The absolute systemic availability after intramuscular administration was 78.5% (range: 59.3-106%) and the harmonic mean of the terminal half-life was 1098 minutes, indicating slow release of the florfenicol from the formulation at the intramuscular injection site. |
| Databáze: | OpenAIRE |
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