Hypothalamic–pituitary–adrenal axis recovery after treatment of Cushing's syndrome

Autor:	Annemarie Balasko, Karin Zibar Tomsic, Darko Kastelan, Tina Dusek
Rok vydání:	2022
Předmět:	Hypothalamo-Hypophyseal System Cellular and Molecular Neuroscience Endocrinology Hydrocortisone Endocrine and Autonomic Systems Endocrinology Diabetes and Metabolism Humans Pituitary-Adrenal System Cushing Syndrome Glucocorticoids Adrenal Insufficiency
Zdroj:	Journal of Neuroendocrinology. 34
ISSN:	1365-2826 0953-8194
DOI:	10.1111/jne.13172
Popis:	After successful treatment for Cushing's syndrome (CS), secondary adrenal insufficiency develops as a result of the prior suppression of the hypothalamic-pituitary-adrenal (HPA) axis by excess cortisol in the body. Until the recovery of the HPA axis, glucocorticoid replacement therapy is required to enable normal functioning of the body and prevent adrenal crisis. Significant variation in the median time of recovery of the HPA axis is found in various cohorts of CS patients ranging from several weeks to years. Despite the use of physiological glucocorticoid replacement, after cure for CS, patients often experience symptoms of glucocorticoid withdrawal syndrome (GWS). The optimal glucocorticoid regimen to reduce GWS needs to be established and requires an individualized approach aiming to avoid overtreatment at one side and minimize the risk of undertreatment and possible adrenal crisis and GWS on the other side.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71926369fd30681002568d496eb143af https://doi.org/10.1111/jne.13172 Zobrazit plný text záznamu Plný text